New publication in Annals of Neurology (IF: 11.9): Thalamic and extra-thalamic mechanisms of consciousness after severe brain injury

Lutkenhoff E.S., Chiang J., Tshibanda L., Kamau E., Kirsch M., Pickard J.D., Owen A.M., Monti M.M. (2015) Thalamic and extra-thalamic mechanisms of consciousness after severe brain injuryAnnals of Neurology. [ePub ahead of print].

Traditionally the thalamo-cortical axis is believed to be crucial for the maintenance/recovery of consciousness after brain injury as well as cortical/behavioral arousal. Evan Lutkenhoff (MontiLab post-doc) shows, in a paper now in press in Annals of Neurology, that while the degree of thalamic atrophy is proportional to a patient’s inability to produce voluntary behavior and communicate, the impairment in arousal is unrelated to thalamic atrophy. Rather, level of arousal was connected to the degree of atorphy within the basal ganglia (putamen/globus pallidus).

Lutkenhoff_SubcorticalAtrophyAtrophy in Patients as compared to Healthy Volunteers

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Atrophy correlating with clinical scores of motor behavior/communication and arousal

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New Publication in Neurology (IF: 8.3; with editorial): Thalamo-frontal connectivity mediates top-down cognitive functions in disorders of consciousness

A new MontiLab paper published in Neurology (IF: 8.3) demonstrating the importance of thalamo-frontal connectivity in cognitive function for patients with Disorders of Consciousness.

Monti M.M., Rosenberg M., Finoia P., Kamau E., Pickard J.D., Owen A.M. (2015) Thalamo-frontal connectivity mediates top-down cognitive functions in disorders of consciousness. Neurology, 85:1-7. [Pub ahead of print].

See also the accompanying Editorial by S. Goldman and N. Schiff.